Telomerase-inhibitory effects of sugar-modified nucleotide analogs
نویسندگان
چکیده
منابع مشابه
Interaction of deoxyguanosine nucleotide analogs with human telomerase.
To maintain the telomeres at the ends of the chromosomes, telomerase in human cells adds a repeating sequence of nucleotides (TTAGGG) to the 3'-end of each chromosome using an RNA component of the enzyme as the template for DNA synthesis. Because of the selective expression of this enzyme in cancer cells, we have evaluated the interaction of human telomerase with several deoxyguanosine nucleoti...
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The ribonucleoprotein enzyme telomerase is a specialized type of cellular reverse transcriptase which synthesizes one strand of telomeric DNA, using as the template a sequence in the RNA moiety of telomerase. We analyzed the effects of various nucleoside analogs, known to be chain-terminating inhibitors of retroviral reverse transcriptases, on Tetrahymena thermophila telomerase activity in vitr...
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ژورنال
عنوان ژورنال: Nucleic Acids Symposium Series
سال: 2002
ISSN: 0261-3166,1746-8272
DOI: 10.1093/nass/2.1.221